But some universal truths still hold most importantly the more you take the greater the effects. For most drugs there is an optimum dose at which the balance of positives and negatives is about as good at it gets. A dose of about 80mg of MDMA not necessarily all at once for most people without tolerance and assuming average body weight gives them the pleasurable effects of energy, euphoria and empathy, which outweigh the negative effects that become more common with bigger doses such as nausea, panic, paranoia, agitation and gurning.
Higher doses tend to leave people feeling too wasted for too long and being less able to enjoy the people around them and their environment. More MDMA is not more fun. The current average dose of MDMA used in a session across many countries is over mg. GDS thinks for most people this too much. Using less MDMA less often for most people might actually be a way to a better time.
Other than having an enhanced experience there are other benefits of keeping your dose down and using less frequently. These include a less intense and prolonged comedown and the avoidance of tolerance. It might surprise you that most users of MDMA use 10 times or less per year.
Using less than monthly gives your brain especially serotonin levels and body time to recover and return to baseline. Some of the more dangerous contaminants found in pills include PMA paramethoxyamphetamine , which is more toxic at lower doses than ecstasy; N-Ethylpentylone , a cathinone which is a lot more potent than MDMA making it easier to take too much; and NBOMes N-methoxybenzyl , which is more toxic at lower doses than other hallucinogenic drugs and can cause heart attack, renal failure, and stroke.
Sometimes these drug mixes are unexpected and sometimes people take multiple drugs deliberately. Read more: While law makers squabble over pill testing, people should test their drugs at home. Heatstroke or hyperthermia dangerously high body temperature is one of the most common issues among people taking MDMA.
MDMA increases body temperature and sweating, and using it is often accompanied by physical activity such as dancing in a hot environment such as a crowded venue or in the summer heat , exacerbating fluid loss. The effect of ecstasy can be exacerbated by consuming alcohol. Alcohol is a diuretic, so it makes you urinate more and increases dehydration. Dehydration increases risk of heatstroke. Heatstroke can cause brain, heart, kidney and muscle damage, and if left untreated can cause serious complications or death.
If active, people taking MDMA should drink around ml two cups of water an hour and take regular breaks. Isotonic drinks such as Powerade and Gatorade are also OK.
People using MDMA can get really thirsty. But if you have too much water the ratio of salts and water in the body becomes unbalanced — basically the level of salt in your body gets too low and your cells start swelling with water. The technical name is hyponatraemia. MDMA is an anti-diuretic, so it makes you retain water, which can increase risk of water intoxication. Conclusions: MDMA is the major active drug in ecstasy pills, but there is a high degree of variation in doses.
Use of multiple pills over the course of one session is common and results in a sustained increase in MDMA plasma concentrations over a number of hours. This is likely to lead to a much greater exposure of the brain to MDMA than would be predicted from controlled single-dose pharmacokinetic studies.
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